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Link Between Low Birth Weights and Obesity Later in Life: Altering Hormone Levels Changes Cellular Development in the Brain

 

ScienceDaily (June 21, 2011) — In a study that increases the understanding of the link between fetal development and obesity later in life, researchers at Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) found altering the levels of two common hormones, insulin and leptin, in utero changes the cellular development in the region of the brain that regulates appetite.

Their study using fetal neural stem cells from animal models, which was published online by the journal, Endocrinology, found that altered levels of leptin or insulin may have marked effects on their offspring brain development. The researchers said these findings provide further clues to the causes of obesity.

With more than 60% of American adults overweight and more than one in five obese, researchers are closely examining the causes. Obesity is a serious health concern for children and adolescents, as well. About 17% of children and adolescents ages 2-19 years are obese. In the past, Type 2 diabetes occurred mostly in middle-aged people. Today, this type of diabetes is seen in 11% of children and adolescents.

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